Детальная информация

Четвертая мини-конференция с международным участием проводится в рамках реализации проекта «Инфекционные болезни и антимикробная терапия» в Научном центре мирового уровня «Центр персонализированной медицины» (при финансовой поддержке Министерства науки и высшего образования Российской Федерации, Соглашение № 075-15-2022-302 от 20.04.2022 г.). Мини-конференция посвящена перспективам разработки новых антибиотиков на основе антимикробных пептидов (АМП) как средств борьбы с бактериями с множественной лекарственной устойчивостью, вызывающими больничные инфекции, включая возникающие в течение или после COVID‑19. Будут рассмотрены различные структурные классы АМП как матрицы для создания новых эффективных препаратов (α-спиральные, β-структурные, пролин-богатые пептиды), обсуждены «за» и «против» этих веществ. Рассмотрено применение АМП в комбинации с конвенциональными антибиотиками, а также с наночастицами металлов. Обсуждены другие типы биологической активности АМП: иммуномодулирующие, противоопухолевые свойства, взаимодействие АМП с системой комплемента. Главная задача мини-конференции – поиск новых путей научного сотрудничества. Мини-конференция приурочена к 300-летию Российской академии наук.

The IV Mini-Сonference with International Participation is holding in the frame of realization of the project “Infectious diseases and antimicrobial therapy” at the World-Class Research Centre for Personalized Medicine (with the financial support of the Ministry of Science and Higher Education of the Russian Federation, Agreement № 075-15-2022-302). The Mini-Сonference is devoted to the prospects of developing novel antibiotics on the base of antimicrobial peptides (AMPs) as tools for combating multidrug resistant bacteria causing severe hospital infections including those arising during or after COVID‑19. Varied structural classes of AMPs will be considered as templates for creation of such potent drugs (α-helical, β-hairpin, proline-rich peptides), the pros and cons of these substances will be discussed. An application of AMPs in combination with conventional antibiotics as well as with metal nanoparticles also will be under consideration. Other types of the biological activity of AMPs will be discussed: immunomodulatory, anti-tumor activities, interaction of AMPs with the complement system. The main aim of the Mini-Conference is finding new ways for scientific collaboration. The Mini-Сonference is dedicated to the 300th anniversary of the Russian Academy of Sciences.

• CONTENTS
• SCIENTIFIC PROGRAM
• Day 1: 18 July 2024
• Day 2: 19 July 2024
• Poster session reports
• ABSTRACTS
• Oral reports
• Shamova et al. Creation of new antibiotics based on natural antimicrobialpeptides of the family of cathelicidins: the first steps towards introduction into medicine
• Oshchepkova, Shamova. Prospects for using antimicrobial peptides astherapeutic agents
• Egorov et al. The use of amyloidogenic peptides as drugs: issues andprospects
• Chernov et al. Glioblastoma multiforme and immune microenvironment:sensitivity to antimicrobial peptides LL-37, PG-1 and chemotherapy forprediction of overall survival of the patients
• Krenev et al. All we know about complement C3f peptide
• Galianova. Dendrimeric peptides as a new approach to improveantimicrobial agents
• Smetanin et al. Unexpected discovery of β-hairpin AMP in leglessamphibians: a new hope in the fight against multidrug-resistant pathogens
• Nizhnikov. Prokaryotic amyloids: functions and interactions
• Fayoud et al. Dps protein of Salmonella enterica shows amyloidproperties in vitro
• Gusev. Исследование аллоферона (аллокина-альфа) -иммуномодулирующего антимикробного пептида естественного происхождения и его аналогов
• Ryzhova et al. Neuroimmunomodulating effects of endogenous antibioticdefensin (HNP 1) and proinflammatory cytokine interferon α2b on the ionotropic glutamate receptor function in the frog vestibular epithelium
• Oborin et al. Cooperativity of endogenuos antimicrobial polypeptides
• Mirzoeva et al. Heterologous production of lanthipeptides based on class III lanthionine synthetase ANCKC
• Ilina. Prospects for Alzheimer’s disease therapy with peptide compounds
• Botros et al. Exploring the antimicrobial properties of syntheticanalogues of natural cationic peptides and their structural modifications
• POSTER REPORTS
• Egidarova et al. Discovery of novel inhibitors of bacterial arginine deiminase
• Egorova et al. Physiological activity of complement C3 derivatives in killing bacteria
• Filatenkova et al. Interleukin-1 receptor antagonist as a way of postviral chronic fatigue syndrome correction
• Eresko et al. Prolonged alcoholism changes the mrna content of the SMIM20 gene in the brain of rats during alcohol withdrawal
• Kostina et al. The effect of the synthetic analogue of kisspeptin on the level of testosterone and follicle-stimulating hormone in fish Danio rerio
• Kosyakova et al. Preclinical studies of antimutagenic safety and genoprotective properties of ANTHORЕX and AGRЕLAX peptides
• Krenev. Machine learning using multiple logistic regression for antimicrobial and hemolytic peptides prediction and its application for their identification in large proteins
• Nuzhnova et al. Dynamics of cortisol changes under the effect of thesynthetic analogue of kisspeptin 1 in fish Danio rerio
• Oborin et al. Isolation of antimicrobial polypeptides from blood serum
• Orlov et al. Bactericidal mechanism of a β–hairpin peptide protegrin-1
• Shanin et al. Prospects of peptides use in traumatic brain injury. Experimental research
• Sukhareva, Shamova. Evaluation of the combined action of salivaryproline-rich peptides with conventional antibiotics or cathelicidin LL-37 on bacterial biofilm formation
• Vladimirova, Shamova. Development of new approaches for correction of infectious pathology caused by antibiotic-resistant bacteria using combinations of natural peptides, antibiotics and nanomaterials
• Yuskina et al. Antibiotic susceptibility testing with high-frequency contactless sensor
• Zharkova et al. Anticancer properties of hybrid cationic peptides based on tryptophan-, leucine- and proline-rich sequences
• Abstracts without reports
• Berezhnoy et al. Gene expression of antimicrobial peptides in rat intestine under conditions of chronic stress
• Landynya et al. Cytotoxicity in vitro of combinations of antimicrobial peptide LL-37 and temozolomide on glioblastoma cells
• Leonova, Grishina. Antimicrobial proteins from the venom of Vipera berus
• Litvinova et al. The effect of intranasal oxytocin on the central nervous system
• Lizunova et al. Kisspeptin synthetic peptides modulates the expression of the of the corticolhyberin and gonadoliberin genes in the midbrain of Danio rerio
• Perova et al. Kisspeptin 10 reduces the manifestations of sexual dysfunction in rats in models of acute psychogenic stress