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Enhanced heat transfer is critical in today’s industrial and engineering applications. Numerous studies have explored ways to improve heat transfer by inducing turbulence through swirl flows. While extensive experimental and numerical studies have been conducted on twisted pipe performance, fewer numerical studies have focused on periodic and non-periodic conditions of twisted pipes configuration. Therefore, numerical simulations were performed for periodic and non-periodic conditions. This study analyzed Laminar and turbulent k-epsilon (two-equation) model for incompressible Newtonian fluid using ANSYS R2 student’s version 2024, using water as working fluid, and a square twisted pipe as the computation model. The current study covers Reynolds numbers in the range 1000-15000. Average friction factor and Nusselt number obtained were verified and validated against results of experimental and numerical results of [1, 2, 3]. Results showed that due to swirl induced by twisting the pipe’s geometry, the critical Reynolds number for the beginning of transition to turbulence was reduced. The thermal enhanced factor (TEF) that quantifies the heat transfer enhancement at the penalty of pressure drop was used to compare twisted and smooth straight pipe. Based on this, the twisted pipe performed better both for low and high Reynolds number (1000<Re<15000) in turbulent and laminar regimes.