Details
| Title | Protective potential of medium-chain triglycerides in a model of LPS-induced cognitive dysfunction: выпускная квалификационная работа магистра: направление 12.04.04 «Биотехнические системы и технологии» ; образовательная программа 12.04.04_01 «Молекулярные и клеточные биомедицинские технологии (международная образовательная программа) / Molecular and Cellular Biomedical Technologies (International Educational Program)» |
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| Creators | Ким Елизавета Андреевна |
| Scientific adviser | Карпенко Марина Николаевна |
| Organization | Санкт-Петербургский политехнический университет Петра Великого. Институт биомедицинских систем и биотехнологий |
| Imprint | Санкт-Петербург, 2026 |
| Collection | Выпускные квалификационные работы ; Общая коллекция |
| Subjects | capric acid ; caprylic acid ; neonatal inflammation ; cognitive impairments ; working memory ; neuroplasticity |
| Document type | Master graduation qualification work |
| Language | Russian |
| Level of education | Master |
| Speciality code (FGOS) | 12.04.04 |
| Speciality group (FGOS) | 120000 - Фотоника, приборостроение, оптические и биотехнические системы и технологии |
| DOI | 10.18720/SPBPU/3/2026/vr/vr26-4705 |
| Rights | Доступ по паролю из сети Интернет (чтение, печать, копирование) |
| Additionally | New arrival |
| Record key | ru\spstu\vkr\45231 |
| Record create date | 9/7/2026 |
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| Group | Anonymous |
|---|---|
| Network | Internet |
The given work is devoted to investigations of the effect of medium-chain triglycerides (MCTs) on cognitive impairments in adult male Wistar rats in a model of neonatal inflammation (LPS, 25 μg/kg on days 15, 18, and 21 of postnatal development). Adult animals received 3 g/kg MCFA daily for 28 days. Working and spatial memory, behavior, blood metabolite and cytokine levels, and the expression of Mmp9, Timp1, and NMDA/AMPA receptor subunits in the cortex and hippocampus were assessed. MCFA improved working memory in animals without inflammation, normalized the pyruvate/lactate ratio, modulated IL-10, TNFα, CX3CL1, and IP-10, reduced Mmp9 expression in the hippocampus, and reorganized the composition of glutamate receptors during inflammation. In contrast to similar experiments in female rats, effects of MCFA on behavioral, immune, and transcriptional levels were observed in males, suggesting the existence of sex differences in the response to neonatal inflammation and the consumption of MCFA triglycerides over a course of treatment.
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