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Table of Contents
- Contents
- Preface
- Chapter One
- 1.1 P4 medicine: predictive, preventive, personalized and participatory
- 1.2 Systems primary care medicine
- 1.3 Causality in P4SM
- 1.4 Explanation, prediction and control in P4 me
- 1.5 What P4 medicine does
- 1.6 Examples of P4 medicine
- 1.7 Important collaborations in P4 medicine
- 1.8 P4 and evidence based medicine
- 1.9 The Advancing Regulatory Science Initiative
- 1.10 The voices of the people
- 1.11 Limitations of P4 medicine
- 1.12 Metabolomics
- 1.12.1 Introduction
- 1.12.2 Comparison of LC-MS and GC-MS
- 1.12.3 NMR in metabolomics
- 1.12.4 Receiver operator characteristic (ROC) curves
- 1.12.5 Acute kidney injury (AKI) metabolomics
- 1.12.6 Chronic kidney disease (CKD) me
- 1.12.7 Metabolomics of acute kidney injury
- 1.12.8 Metabolomics of neonatal, pediatric and childhood kidney diseases
- 1.12.9 Metabolomics of kidney cancer
- 1.12.10 Proteomics
- 1.13 Targeted radiation therapy
- 1.14 Precision systems medicine that targets cancer stem cel
- 1.15 Cancer prevention
- 1.16 Systems medicine
- References
- Chapter Two
- 2.1 Previous misconceptions caused by reductionist thinking
- 2.2 Chemistry of free radicals and RONS
- 2.3 How antioxidants really work
- 2.3.1 Poorly liganded iron and the Fenton reaction
- 2.3.2 The Nrf2/ARE system
- 2.4 The role of the Keap1-Nrf2-ARE signaling system in preventing cardiovascular diseases
- 2.5 Role of the Nrf2/ARE antioxidant system in cancer and neurodegenerative diseases
- 2.6 Smoldering inflammation
- 2.7 The complement system and toll-like receptors in health and disease
- References
- Chapter Three
- 3.1 Nutrition
- 3.1.1 Fats
- 3.1.2 Protein
- 3.1.3 Carbohydrates
- 3.1.4 Vitamins and
- 3.1.5 Mother’s milk – the only true superfood
- 3.2 Role of Lifestyle
- References
- 3.1 Nutrition
- Chapter Four
- 4.1 Introduction
- 4.2 Epigenetic gene regulation
- 4.3 Global climate change
- References
- Appendix
- A1 Introduction
- A2 The Nervous System
- A2.1 Introduction
- A2.2 Cells in the nervous system
- A2.3 Regions of the brain
- A2.4 Neurotransmitters, neurohormones and neuromodulators
- A2.5 Small molecule neuroactive NO and CO
- A3 The Endocrine System
- A4 The Immune System
- References
- Abbreviations and Acronyms Used
- Index
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