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Title: Systems thinking in medicine and new drug discovery. Volume two /
Creators: Smith Robert E.,
Collection: Электронные книги зарубежных издательств; Общая коллекция
Subjects: Drug development.; Pharmaceutical chemistry.; Integrative medicine.; Human biology.; MEDICAL / Pharmacology; EBSCO eBooks
Document type: Other
File type: PDF
Language: English
Rights: Доступ по паролю из сети Интернет (чтение, печать, копирование)
Record key: on1081038825

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Table of Contents

  • Contents
  • Preface
  • Chapter One
    • 1.1 P4 medicine: predictive, preventive, personalized and participatory
    • 1.2 Systems primary care medicine
    • 1.3 Causality in P4SM
    • 1.4 Explanation, prediction and control in P4 me
    • 1.5 What P4 medicine does
    • 1.6 Examples of P4 medicine
    • 1.7 Important collaborations in P4 medicine
    • 1.8 P4 and evidence based medicine
    • 1.9 The Advancing Regulatory Science Initiative
    • 1.10 The voices of the people
    • 1.11 Limitations of P4 medicine
    • 1.12 Metabolomics
      • 1.12.1 Introduction
      • 1.12.2 Comparison of LC-MS and GC-MS
      • 1.12.3 NMR in metabolomics
      • 1.12.4 Receiver operator characteristic (ROC) curves
      • 1.12.5 Acute kidney injury (AKI) metabolomics
      • 1.12.6 Chronic kidney disease (CKD) me
      • 1.12.7 Metabolomics of acute kidney injury
      • 1.12.8 Metabolomics of neonatal, pediatric and childhood kidney diseases
      • 1.12.9 Metabolomics of kidney cancer
      • 1.12.10 Proteomics
    • 1.13 Targeted radiation therapy
    • 1.14 Precision systems medicine that targets cancer stem cel
    • 1.15 Cancer prevention
    • 1.16 Systems medicine
    • References
  • Chapter Two
    • 2.1 Previous misconceptions caused by reductionist thinking
    • 2.2 Chemistry of free radicals and RONS
    • 2.3 How antioxidants really work
      • 2.3.1 Poorly liganded iron and the Fenton reaction
      • 2.3.2 The Nrf2/ARE system
    • 2.4 The role of the Keap1-Nrf2-ARE signaling system in preventing cardiovascular diseases
    • 2.5 Role of the Nrf2/ARE antioxidant system in cancer and neurodegenerative diseases
    • 2.6 Smoldering inflammation
    • 2.7 The complement system and toll-like receptors in health and disease
    • References
  • Chapter Three
    • 3.1 Nutrition
      • 3.1.1 Fats
      • 3.1.2 Protein
      • 3.1.3 Carbohydrates
      • 3.1.4 Vitamins and
      • 3.1.5 Mother’s milk – the only true superfood
    • 3.2 Role of Lifestyle
    • References
  • Chapter Four
    • 4.1 Introduction
    • 4.2 Epigenetic gene regulation
    • 4.3 Global climate change
    • References
  • Appendix
    • A1 Introduction
    • A2 The Nervous System
      • A2.1 Introduction
      • A2.2 Cells in the nervous system
      • A2.3 Regions of the brain
      • A2.4 Neurotransmitters, neurohormones and neuromodulators
      • A2.5 Small molecule neuroactive NO and CO
    • A3 The Endocrine System
    • A4 The Immune System
    • References
  • Abbreviations and Acronyms Used
  • Index

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