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Table Card RUSMARC
Title: Solubility in pharmaceutical chemistry
Other creators: Saal Christoph; Nair Anita
Collection: Электронные книги зарубежных издательств; Общая коллекция
Subjects: Drugs — Solubility.; Pharmaceutical chemistry.; Solubility.; Drugs.; Solubility; Chemistry, Pharmaceutical; Pharmaceutical Preparations; Médicaments — Solubilité.; Chimie pharmaceutique.; Solubilité.; Médicaments.; MEDICAL — Pharmacology.; Drugs — Solubility; Pharmaceutical chemistry; EBSCO eBooks
Document type: Other
File type: PDF
Language: English
Rights: Доступ по паролю из сети Интернет (чтение, печать, копирование)
Record key: on1135589155

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Annotation

This book describes the physicochemical fundamentals and biomedical principles of drug solubility. Methods to study and predict solubility in silico and in vitro are described and the role of solubility in a medicinal chemistry and pharmaceutical industry context are discussed. Approaches to modify and control solubility of a drug during the manufacturing process and of the pharmaceutical product are essential practical aspects of this book.

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Table of Contents

  • Contents
  • List of contributors
  • 1. Solubility – definition and basic physicochemical considerations
  • 2. Solubility and supersaturation
  • 3. In Silico methods to predict solubility
  • 4. How solubility influences bioavailability
  • 5. Estimation of intraluminal drug solubility
  • 6. Biorelevant media
  • 7. The role of solubility to optimize drug substances – a medicinal chemistry perspective
  • 8. The role of solubility in optimizing drug products – a pharmaceutical development perspective
  • 9. The relevance of solid-state forms for solubility
  • 10. Solubility and phase behaviour from a drug substance manufacturing perspective
  • 11. Biowaivers
  • List of Abbreviations
  • Index

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