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Modern acoustics has blossomed rapidly in the past decades. Beginning as a branch off from the classical physics, modern acoustics has become an interdisciplinary science that has exceeded the boundaries of its origins. As a result, the demand for graduate students, professionals and specialists who need to master the knowledge of acoustics is growing quickly. The primary goal of this publication is to meet this urgent need by providing an updated, comprehensive reference book that educates readers on both fundamental concepts as well as their broader applications in the fast-moving technological world. The Handbook of Contemporary Acoustics and Its Applications systematically covers the theoretical principle and analytical methodology of generation, propagation and reception of acoustic waves in an ideal (inviscid) and non-ideal fluid media. The topics include the transduction, radiation, scattering, diffraction and reception of the acoustic wave. It also discusses the acoustic field in a duct/pipe, waveguide and cavity, the wave propagation in the multi-layers, nonlinear finite amplitude wave propagation and the mechanisms of physical and biological effects and their broad modern applications such as sonoporation, targeted drug delivery, acoustic tweezers, noninvasive high intensity focused ultrasound (HIFU) surgery, as well as sonoluminscence. Readers are also provided with the fundamental mathematic background and relevant references necessary for their creative inventions and applications. This handbook is intended for senior undergraduate and graduate students, as well as specialists working in relevant fields, and may be used as a textbook in courses covering acoustics.