This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.

• Preface
• Contents
• Contributing authors
• List of abbreviations
• 1. Induced pluripotent stem-cell-derived cardiomyocytes (iPSC-CMs): novel diagnostic platform
• 2. Preclinical large-animal models of cardiovascular regeneration
• 3. Cell-free therapy with stem cell secretions: protection, repair, and regeneration of the injured myocardium
• 4. Myoblasts provide safe and effective treatments for hereditary muscular dystrophies, cardiomyopathies, type 2 diabetes, solid tumors, and aging
• 5. Stem cells in ophthalmology
• 6. Stem cells for ocular therapies
• 7. Cell therapy for liver regeneration
• 8. Patient-specific induced pluripotent stem cells for cardiac disease modeling
• 9. Role of stem cells on evolution: a hypothesis
• Index